講師：Prof. Amy Shen (OIST)
題目：Novel nano- and microfabrication techniques for micro/nanofluidics and biosensing applications
要旨：Micro/nanofluidics has emerged in recent years as a powerful method of manipulating fluids at small length-scales. To highlight their versatility and great potentials, I present 3 micro/nanofluidic platforms with applications in enhanced micromixing, nanofluidic immunoassay, and localized surface plasmon resonance (LSPR) sensing.
(a) Enhanced micro-mixing: we present a summary of our recent results examining flow instabilities arising in stagnation point flows generated in cross-slot-type geometries. Our studies span purely inertial flows of simple Newtonian fluids, through inertio-elastic flows of highly dilute polymer solutions, to purely-elastic instabilities in more concentrated polymeric systems [1,2].
(b) Making Waves in a Total Capture Nanofluidic Immunoassay: understanding nanoconfinement phenomena is necessary to develop nanofluidic technology platforms. We demonstrate a convection limited nanofluidic immunoassay that achieves total capture of a target analyte, and an apparent shift in the reaction equilibrium due to nanoconfinement .
(c) We introduce a new nanofabrication procedure for localized surface plasmon resonance (LSPR) sensing with applications in sensitive bioassays and long term live-cell biosensing [4.5].
 N. Burshtein, K Zografos, A. Q. Shen, R. J. Poole, and S. J. Haward, Inertioelastic flow instability at a stagnation point, Physical Review X, 7, 041039-18, 2017.
 S. J. Haward, R. J.Poole, M. A. Alves, P. J. Oliveira, N. Goldenfeld, A. Q. Shen, Tricritical spiral vortex instability in cross-slot flow, Physical Review E, 93: 031101, 2016.
 C. J. Galvin, K. Shirai, A. Rahmani, K. Masaya, and A. Q. Shen, Total Capture, Convection-Limited Nanofluidic Immunoassays Exhibiting Nanoconfinement Effects, Analytical Chemistry, 2018. DOI: 10.1021/acs.analchem.7b04664
 N. Bhalla, S. Sathish, A. Sinha, and A. Q. Shen, Large-scale nanophotonic structures for long-term monitoring of cell proliferation, Advanced Biosystems, 1700258, 2018.
 N. Bhalla, S. Sathish, C. J. Galvin, R. A. Campbell, A. Sinha, and A. Q. Shen, Plasma assisted large-scale nanoassembly of metal insulator bioplasmonic mushrooms, ACS Applied Materials & Interfaces, 2017.