２０１８年９月１１日 Hsuan-Yi Chen氏

日時：２０１８年９月１１日（火）　１１：００〜１２：３０
場所：首都大学東京　８号館３０４号室
講師：Hsuan-Yi Chen氏 (National Central University, Taiwan)
題目：Minimal model for epithelia steady state

要旨：The steady state of a epithelium is maintained by carefully regulated cell division, cell differentiation and cell apoptosis. The result is a robust spatial distribution of niches of proliferative cells and precisely regulated tissue size. We propose a minimal general model using least assumptions from empirical observations and conservation laws to study the properties of the steady states in epithelia. In a stratified epithelium we also compare the degree of stratification of two cell lineage models and compare to experimental observation on mouse olfactory epithelia. The main results are (i) for a stratified steady state to exist, the cells in a tissue need to know their distance from the basal membrane by some long range interaction such as mechanical stress or morphogen density, (ii) interaction due to direct cell-cell contacts tend to drive the tissue to a homogeneous state, therefore when both long-range interaction and interactions due to direct cell-cell contact are present, it is possible for the tissue to have two steady states. The relation between multistability and wound healing, tissue development are discussed. At the end of this talk, further generalization of our model to other types of epithlia will be discussed.